Quality of Life in Hidradenitis Suppurativa: validation of the HSQoL-24.

To date, there are no disease-specific instruments in Spanish to assess quality of life of patients with hidradenitis suppurativa. A multicentre study was previously carried out in Spain between 2016 and 2017 to develop the Hidradenitis Suppurativa Quality of Life-24 (HSQoL-24), a disease-specific questionnaire to assess quality of life in patients with hidradenitis suppurativa. The objectiv-es of this study are to revalidate the HSQoL-24 in Spanish with a larger sample of patients, and to present the English version. In this multi-centre study in Spain, patients with hidradenitis suppurativa completed the HSQoL-24, the Dermatology Life Quality Index and the Skindex-29. The Hurley staging system was used to assess the severity of the disease. Validation of the questionnaire was carried out in 130 patients, of whom 75 (57.7%) were women. This study demonstrates adequate values of reliability and validity of the HSQoL-24, confirming the previous test re-test validation and making this questionnaire one of wide clinical validity in terms of results perceiv-ed by patients.

Cold panniculitis.

Cold panniculitis has been described in children and young women following cold exposure. Histopathologically, cold panniculitis shows a mostly lobular panniculitis, which consists of an infiltrate of lymphocytes and histiocytes in the fat lobules. Usually, the dermis shows a superficial and deep perivascular infiltrate mostly composed of lymphocytes, with no vasculitis. Inflammation is most intense at the dermal-subcutaneous junction. Differential diagnosis of cold panniculitis should be established with subcutaneous fat necrosis of the newborn, sclerema neonatorum, poststeroid panniculitis, chilblains, and frostbites.

[Annular elastolytic giant cell granuloma: a case report located in non-sun exposed areas]. / Granuloma elastolítico anular de células gigantes: a propósito de un caso localizado en áreas no fotoexpuestas.

Annular elastolytic giant cell granuloma (AEGCG) is an uncommon entity clinically characterized by erythematous annular plaques with atrophic and hypopigmented center, that predominates in sun-exposed zones. The histology shows a granulomatous infiltrate without palisading image, made up of lymphocytes, histiocytes and giant cells, with phagocytosis of elastic fibers, without necrobiosis or mucin deposit. We present the case of a male patient with atypical clinical manifestation on the non-sun exposed skin and AEGCG characteristic histology.

Granuloma elastolítico anular de células gigantes: a propósito de un caso localizado en áreas no fotoexpuestas / Annular elastolytic giant cell granuloma: a case report located in non-sun exposed areas

El granuloma elastolítico anular de células gigantes (GEACG) es una entidad poco frecuente, caracterizada clínicamente por placas eritematosas anulares de centro atrófico e hipopigmentado, que predominan en zonas fotoexpuestas. En la histología presentan un infiltrado granulomatoso sin formación de imagen en empalizada, compuesto por linfocitos, histiocitos y células gigantes, con fagocitosis de fibras elásticas, sin necrobiosis ni depósito de mucina. Presentamos el caso de un paciente con manifestaciones clínicas atípicas en piel no fotoexpuesta, y una histología característica de GEACG

Annular elastolytic giant cell granuloma (AEGCG) is an uncommon entity clinically characterized by erythematous annular plaques with atrophic and hypopigmented center, that predominates in sun-exposed zones. The histology shows a granulomatous infiltrate without palisading image, made up of lymphocytes, histiocytes and giant cells, with phagocytosis of elastic fibers, without necrobiosis or mucin deposit. We present the case of a male patient with atypical clinical manifestation on the non-sun exposed skin and AEGCG characteristic histology

Pápulas eritematoanaranjadas faciales / Orangish-erythematous facial papules

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Síndrome de hipersensibilidad a sulfasalacina en paciente VIH / Drug hypersensitivity syndrome to sulfasalazine in an HIV patient

El síndrome de hipersensibilidad a fármacos se define por la triada clínica de fiebre, erupción cutánea y afectación de órganos internos. Múltiples fármacos se asocian con sintomatología cutánea aislada (exantema o erupción maculopapulosa), mientras que sólo unos pocos fármacos se asocian con el síndrome de hipersensibilidad. Fármacos relacionados con este síndrome son los anticonvulsivantes, antibióticos, sulfasalazinas y antirretrovirales. A pesar de las múltiples reacciones medicamentosas descritas en estos pacientes, este es el primer caso de síndrome de hipersensibilidad a sulfasalazina en un paciente con infección por el VIH que se recoge en la literatura dermatológica

Drug hypersensitivity syndrome is defined by the clinical triad of fever, rash, and internal organ involvement. Numerous drugs have been associated with isolated cutaneous eruptions (particularly of the simple exanthematic or maculopapular type), while only a limited number of drugs are associated with drug hypersensitivity syndrome. Drugs commonly associated with drug hipersensitivity syndrome in elude the anticonvulsants, antibiotics, sulfasalazines and antiretrovirals. Despite the numerous drug reactions described in HIV patients, up to our knowledge, this is the first case, of drug hypersensitivity syndrome to sulfasalazines in an HIV patient has not been previously reported

Granuloma por silicona líquida / Granuloma from liquid silicone

En los últimos años, ha aumentado la demanda de intervenciones estéticas de relleno de partes blandas mediante inyección de diversas sustancias, dada su aparente inocuidad. Sin embargo, estos procedimientos no están exentos de reacciones adversas, como la formación de granulomas de cuerpo extraño, fenómeno descrito en la literatura médica con la mayoría de los materiales utilizados. Comunicamos el caso de una paciente con lesiones inflamatorias en la cara cuyo diagnóstico se efectuó tras el estudio histopatológico y que permitió la observación de un granuloma por silicona líquida

In recent years, the demand for cosmetic interventions to augment soft tissue by injecting different substances has increased, due to their apparent innocuity. However, these procedures are not free from adverse reactions, such as the formation of foreign body granulomas, a phenomenon described in literature with most of the materials used. We report the case of a female patient with inflammatory lesions of the face, whose diagnosis was made after the histopathological study, which revealed a granuloma caused by liquid silicone

Pénfigo herpetiforme asociado a carcinoma de esófago / Herpetiform pemphigus associated with esophageal carcinoma

Presentamos el caso de una mujer de 63 años con un pénfigo herpetiforme y un carcinoma de esófago diseminado que comenzaron a manifestarse de forma simultánea. Se han comunicado previamente algunos casos de pénfigo herpetiforme asociados con neoplasias, pero éstas han sido fundamentalmente broncopulmonares. La asociación de cualquier variedad de pénfigo y cáncer de esófago es muy infrecuente. Debemos estar atentos ante las variedades infrecuentes de pénfigo y las enfermedades ampollosas atípicas, porque a veces no cumplen los criterios diagnósticos de pénfigo paraneoplásico, pero son la primera manifestación de una neoplasia subyacente

We present the case of a 63-year-old woman with herpetiform pemphigus and disseminated esophageal carcinoma which began to manifest themselves simultaneously. Some cases of herpetiform pemphigus associated with neoplasms have previously been reported, but these have primarily been bronchopulmonary. The association of any type of pemphigus with esophageal cancer is very infrequent. We should be alert to the infrequent varieties of pemphigus and atypical bullous diseases, because they sometimes do not meet the diagnostic criteria of paraneoplastic pemphigus, but are the first manifestation of an underlying neoplasm

[Granuloma from liquid silicone]. / Granuloma por silicona líquida.

In recent years, the demand for cosmetic interventions to augment soft tissue by injecting different substances has increased, due to their apparent innocuity. However, these procedures are not free from adverse reactions, such as the formation of foreign body granulomas, a phenomenon described in literature with most of the materials used. We report the case of a female patient with inflammatory lesions of the face, whose diagnosis was made after the histopathological study, which revealed a granuloma caused by liquid silicone.

[Herpetiform pemphigus associated with esophageal carcinoma]. / Pénfigo herpetiforme asociado a carcinoma de esófago.

We present the case of a 63-year-old woman with herpetiform pemphigus and disseminated esophageal carcinoma which began to manifest themselves simultaneously. Some cases of herpetiform pemphigus associated with neoplasms have previously been reported, but these have primarily been bronchopulmonary. The association of any type of pemphigus with esophageal cancer is very infrequent. We should be alert to the infrequent varieties of pemphigus and atypical bullous diseases, because they sometimes do not meet the diagnostic criteria of paraneoplastic pemphigus, but are the first manifestation of an underlying neoplasm.

Asociación entre dos enfermedades neuromusculares de base inmunológica: esclerosis múltiple y dermatomiositis / Association between two immunologic neuromuscular disorders: multiple sclerosis and dermatomyositis

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Tratamiento con interferón alfa intralesional de una verruga vírica recalcitrante / No disponible

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Sir James Paget (1814-1899) / Sir James Paget (1814-1899)

James Paget nació en Great Yarmouth, Inglaterra, en 1814. Fue nombrado conservador del museo anatomopatológico del hospital de San Bartolomé, de Londres.Trabajador incansable, en 1874 publicó un artículo en el que relacionaba la aparición de un eccema en el pezón con el desarrollo posterior de un cáncer mamario. Fue nombrado 'Cirujano de la Corte' por la reina Victoria de Inglaterra. Murió en 1899 (AU)

John Templeton Bowen (1857-1940) / John Templeton Bowen (1857-1940)

John T. Bowen nació en 1857 en Boston. Se doctoró en Medicina en la Universidad de Harvard en 1884.Durante tres años perfeccionó sus conocimientos médicos en varias ciudades europeas. Trabajó en el servicio de Dermatología del Hospital General de Massachusetts desde 1889 hasta 1914. Se le recuerda por la descripción de la neoplasia intraepidérmica que lleva su nombre. Murió en 1940 (AU)